Clozapine prescribing

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Clozapine Prescribing in a Canadian Outpatient Population

OBJECTIVE Description of demographics of an outpatient population of clozapine users. METHODS Retrospective chart review study of an urban population diagnosed with schizophrenia. Assessment of therapeutic histories in relation to clinical practice guidelines. RESULTS Seventy-seven of the 467 patients were on clozapine therapy. Average patients' age was 39.4 ± 11.8 years) and 68% were males...

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Clozapine: a review of clinical practice guidelines and prescribing trends

BACKGROUND Clozapine effectiveness in the treatment of refractory schizophrenia has been sustained by published evidence in the last two decades, despite the introduction of safer options. DISCUSSION Current clinical practice guidelines have strongly recommended the use of clozapine in treatment-resistant schizophrenia, but prescribing trends do not appear to have followed such recommendation...

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Contrasting clozapine prescribing patterns in the east and west?

INTRODUCTION Polypharmacy is common in the treatment of schizophrenia and it may be especially common in the East. In this survey, we compared the effect of clozapine, an atypical neuroleptic, on polypharmacy in two groups of patients with schizophrenia in two different settings. MATERIALS AND METHODS The medical charts of patients on stable doses of clozapine from a Canadian psychiatric cent...

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Clozapine prescribing in adolescent psychiatry: survey of prescribing practice in in-patient units

AIMS AND METHOD Clozapine is an effective drug in treatment-resistant schizophrenia, but it seems to be prescribed for few patients under the age of 18 years. This study reports a survey of consultant psychiatrists working in adolescent units in the UK, looking at their use of clozapine and experience with it. RESULTS Out of 83 clinicians, 59 responded (71%). More than 40% of respondents do not...

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Prescribing clozapine and rifampicin: clinical impact of their interaction

The predictable pharmacokinetic drug interaction between clozapine and rifampicin is listed in most standard reference texts but little detail is given or emphasis on its clinical significance. The interaction is based on theoretical knowledge of both drugs; to date just two case reports have been published. This article describes a third case demonstrating the significance of this interaction....

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ژورنال

عنوان ژورنال: Psychiatric Bulletin

سال: 1995

ISSN: 0955-6036,1472-1473

DOI: 10.1192/pb.19.6.376